Endocrine Abstracts

Prostaglandin (PG) E2 has been implicated in benign and neoplastic endometrial pathologies. PGE2 exerts its function by coupling to 4 subtypes of G protein coupled receptors (EP1-EP4). Recently a role for the EP2 receptor in angiogenesis has been established. This study investigated signal transduction and vascular endothelial growth factor (VEGF) expression by the EP2 receptor in Ishikawa endometrial epithelial cells. Ishikawa cells were stably transfect...

The chicken gonadotropin-releasing hormone receptor (cGnRH-R) is notable for having a cytoplasmic carboxyl-terminal tail, which is not present in the mammalian GnRH-Rs. We have previously shown that the cGnRH-R undergoes rapid agonist-induced internalization, and requires the carboxyl-terminal tail for this process. To investigate the role of the carboxyl-terminal tail of the cGnRH-R in relation to its rapid internalization, and to identify the key residues involved, a series ...